| Pair Name | Raddeanin A, Cisplatin | ||
| Phytochemical Name | Raddeanin A (PubChem CID: 174742 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Raddeanin A, Cisplatin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | QGY-7703 | Papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_6715 |
| Result | All these consequences reflect RA plays an important role in enhancing the therapeutic effect of cisplatin in HCC. This finding may guide for the drug usage of cisplatin in clinic practice. | |||
| No. | Title | Href |
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| 1 | Synergy of Raddeanin A and cisplatin induced therapeutic effect enhancement in human hepatocellular carcinoma. Biochem Biophys Res Commun. 2017 Apr 1;485(2):335-341. doi: 10.1016/j.bbrc.2017.02.079. | Click |
